The DivergentCaenorhabditis elegansβ-Catenin Proteins BAR-1, WRM-1 and HMP-2 Make Distinct Protein Interactions but Retain Functional Redundancyin Vivo
نویسندگان
چکیده
منابع مشابه
The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo.
beta-Catenins function both in cell adhesion as part of the cadherin/catenin complex and in Wnt signal transduction as transcription factors. Vertebrates express two related proteins, beta-catenin and plakoglobin, while Drosophila has a single family member, Armadillo. Caenorhabditis elegans expresses three beta-catenin-related proteins, BAR-1, HMP-2, and WRM-1, which are quite diverged in sequ...
متن کاملHMP-1/α-catenin promotes junctional mechanical integrity during morphogenesis
Adherens junctions (AJs) are key structures regulating tissue integrity and maintaining adhesion between cells. During morphogenesis, junctional proteins cooperate closely with the actomyosin network to drive cell movement and shape changes. How the junctions integrate the mechanical forces in space and in time during an in vivo morphogenetic event is still largely unknown, due to a lack of qua...
متن کاملControl of cell polarity by noncanonical Wnt signaling in C. elegans.
The three Caenorhabditis elegans beta-catenin each function in distinct processes: BAR-1 in canonical Wnt signaling that controls cell fates and cell migrations, HMP-2 in cell adhesion and WRM-1 in Wnt signaling pathways that function in conjunction with a mitogen-activated kinase (MAPK) pathway to control the orientations, or cell polarities, of cells that undergo asymmetric cell divisions. In...
متن کاملWnt signaling drives WRM-1/ -catenin asymmetries in early C. elegans embryos
-Catenin regulates cell adhesion and cellular differentiation during development, and misregulation of -catenin contributes to numerous forms of cancer in humans. Here we describe Caenorhabditis elegans conditional alleles of mom-2/Wnt, mom-4/Tak1, and wrm1/ -catenin. We use these reagents to examine the regulation of WRM-1/ -catenin during a Wnt-signaling-induced asymmetric cell division. Whil...
متن کاملThe BAR domain protein PICK 1 regulates cell recognition and 1 morphogenesis by interacting with Neph proteins
3 Martin Höhne, Johannes Lorscheider, Anna von Bardeleben, Matthias Dufner, M. 4 Antonia Scharf, Markus Gödel, Martin Helmstädter, Eva-Maria Schurek, Sibylle Zank, 5 Peter Gerke, Christine Kurschat, Sema Hayriye Sivritas, Elke Neumann-Haefelin, 6 Tobias B. Huber, H. Christian Reinhardt, Bernhard Schermer, Karl-Friedrich 7 Fischbach, Thomas Benzing 8 9 Renal Division, Department of Medicine and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetics
سال: 2001
ISSN: 1943-2631
DOI: 10.1093/genetics/159.1.159